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Abstract. Mucin-type O-linked glycosylation is a fundamental post-translational modification that is involved in a variety of important biological processes. However, the lack of chemical tools to study mucin-type O-linked glycosylation has hindered our molecular understanding of O-linked glycans in many biological contexts. As noted above, the defining feature of mucin O-linked glycosylation compared to other types of glycosylation is the initial addition of GalNAc to Ser/Thr residues of protein substrates. 37 One useful group of metabolic inhibitors of mucin O-linked glycosylation utilizes GalNAc analogs as decoy primers that suppress elaboration of O-linked glycans. 50,51 These unnatural sugars exploit two 2005-11-01 Plasma membrane signaling mucin that promotes activation of the MAPK for the filamentous growth pathway. Partially redundant with the SHO1 osmosensing branch for the activation of STE11.
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Mucins are a family of high molecular weight, heavily glycosylatedproteins (glycoconjugates) produced by 27 Feb 2021 Mucin in the largest biology dictionary online. Free learning resources for students covering all major areas of biology. We are the Max Planck Institute of Molecular Cell Biology and Genetics (MPI- CBG). We do pioneering basic research. 500 curiosity-driven scientists from over Correlation between mucin biology and tumor heterogeneity in lung cancer.
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Prior to adherence to their target tissue, the first barrier that the streptococci encounter is the mucous layer of the respiratory tract. The present study was undertaken to characterize the interaction between mucin, the major glycoprotein component of mucus, and 1997-11-01 · Mucin-2.
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Our research group is part of Mucin Biology Groups at the University of Gothenburg. We are one of few research labs in the world who study the function and regulation of membrane mucins in defending our gastrointestinal tract. 2018-01-15 · The major structural and functional component, mucin is a complex glycoprotein coded by about 20 mucin genes which produce a protein backbone having multiple tandem repeats of Serine, Threonine (ST repeats) where oligosaccharides are covalently O-linked. In collaboration with the wider Mucin Biology Groups cluster at the University of Gothenburg and both national and international partners, the laboratory seeks to develop new tools allowing the identification and characterisation of goblet cell-mediated defence systems. Mucin gels were rapidly colonized by heterogeneous bacterial populations, especially members of the Bacteroides fragilis group, enterobacteria, and clostridia. Intestinal bacterial populations growing on mucin surfaces were shown to be phylogenetically and metabolically distinct from their planktonic counterparts. Abstract.
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The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. pubmed.ncbi.nlm.nih.gov
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As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources.
Aberrant glycosylation occurs in essentially all types of cancers and results in increased sialylation. Thus, when the mucin MUC1 is expressed on cancer cells, it is decorated by multiple short, sialylated O-linked glycans (MUC1-ST). Brendan Dolan currently works at the Department of Medical Biochemistry and Cell Biology, University of Gothenburg.
it is mainly produced by goblet cells, apical cells of the conjunctiva and cornea and the lacrimal gland.
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It is a mucopolysaccharide or glycoprotein that is the chief constituent of mucus. The MUCIN BIOLOGY GROUPS are led by Gunnar C. Hansson, Malin E.V. Johansson, Thaher Pelaseyed, and George Birchenough and are among the major research groups of the Department of Medical Biochemistry at the Sahlgrenska Academy, the Medical Faculty of University of Gothenburg. Mucin Biology Group. Welcome to the Mucin Database 2.1 2019. of The Mucin Biology Groups.
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Mucin-producerande cell-linjer som en modell för mucinsyntes och sekretion in vivo. Docent Julia Davies. Mucosal Biology Group,.
The intestinal mucus proteome is ∼ 50 proteins with a few that are very abundant.